Mentální anorexie z pohledu endokrinologa

Title in English Anorexia nervosa from an endocrinologist's point of view


Year of publication 2023
Type Article in Periodical
Magazine / Source Česko-slovenská pediatrie
MU Faculty or unit

Faculty of Medicine

Keywords anorexia nervosa; osteoporosis; hypothalamic dysfunction; euthyroid sick syndrome; food intake regulation
Description Anorexia nervosa is a complex psychiatric-metabolic-endocrine disease that has the highest mortality rate among psychiatric diseases. Almost all organs and systems are altered by this disease. Changes in the endocrine system mostly represent the body‘s adaptation to starvation, and after regaining the necessary weight and fat mass, they are spontaneously adjusted. However, it does not apply to all changes. There is a disorder of the hypothalamicpituitary axis with manifestations of hypogonadotropic hypogonadism, hypercortisolemia, resistance to growth hormone, thyroid dysfunction, hyponatremia and hypooxytocinemia. The production of antidiuretic hormone can also be altered, and a bone metabolism disorder can be diagnosed relatively early and often persists even after recovering from anorexia nervosa. Recently, changes in the intestinal microbiome, lipid metabolism, cytokine production disorders with the development of autoimmunity, and immune function disorders have also been described.

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