Mikrobiom u atopické dermatitidy
| Title in English | The microbiome and atopic dermatitis |
|---|---|
| Authors | |
| Year of publication | 2023 |
| Type | Conference abstract |
| Citation | |
| Description | The human skin microbiome varies by body region, age and gender. It interacts with the skin barrier and the skin immune system. Patients suffering from atopic dermatitis develop dysbiosis, there is an increased load of Staphylococcus aureus and a reduction of commensal skin bacteria. Especially during the acute phase, a strongly reduced bacterial diversity is observed, as well as the dominance of a single pathogen, Staphylococcus aureus. In patients with atopic dermatitis, the latter worsens the inflammatory process. The production of proteases and toxins further weakens the already seriously impaired barrier function of the skin. However, knowledge about dysbiosis also brings new treatment options for this disease. Antistaphylococcal interventions in atopic dermatitis contribute to the reduction of S. aureus superantigens and proteases while increasing the amount of commensal bacteria that protect healthy skin from pathogen invasion. Indirect methods of therapy affecting the microbiome include the use of emollients, external anti-inflammatory ointments and the administration of monoclonal antibodies. The microbiome can be directly modulated by antibacterial treatment (antiseptics, topical or systemic antibiotics) and, more recently, by using innovative treatments specifically targeting S. aureus (e.g. anti-S. aureus endolysin and autologous bacteriotherapy). |