Molecular Biomarkers of Neuronal Injury in Epilepsy Shared with Neurodegenerative Diseases

Warning

This publication doesn't include Faculty of Medicine. It includes Central European Institute of Technology. Official publication website can be found on muni.cz.

Authors	NEGI Deepika GRANAK Simon SHORTER Susan LEARY Valerie B REKTOR Ivan OVSEPIAN Saak V
Year of publication	2023
Type	Article in Periodical
Magazine / Source	NEUROTHERAPEUTICS
MU Faculty or unit	Central European Institute of Technology
Citation
Web	https://www.sciencedirect.com/science/article/pii/S1878747923000156?via%3Dihub
Doi	http://dx.doi.org/10.1007/s13311-023-01355-7
Keywords	Epileptic seizures; Neurodegeneration; Fluid biomarkers; Neurofilament light chain; Tau protein; Axonal degeneration; Neurogranin
Description	In neurodegenerative diseases, changes in neuronal proteins in the cerebrospinal fluid and blood are viewed as potential biomarkers of the primary pathology in the central nervous system (CNS). Recent reports suggest, however, that level of neuronal proteins in fluids also alters in several types of epilepsy in various age groups, including children. With increasing evidence supporting clinical and sub-clinical seizures in Alzheimer's disease, Lewy body dementia, Parkinson's disease, and in other less common neurodegenerative conditions, these findings call into question the specificity of neuronal protein response to neurodegenerative process and urge analysis of the effects of concomitant epilepsy and other comorbidities. In this article, we revisit the evidence for alterations in neuronal proteins in the blood and cerebrospinal fluid associated with epilepsy with and without neurodegenerative diseases. We discuss shared and distinctive characteristics of changes in neuronal markers, review their neurobiological mechanisms, and consider the emerging opportunities and challenges for their future research and diagnostic use.