MISMATCH-REPAIR DEFICIENCY IS ASSOCIATED WITH A HIGHER RISK OF RECURRENCE THAN NO SPECIFIC MOLECULAR PROFILE IN EARLY-STAGE ENDOMETRIAL CANCER

• Authors: BEDNAŘÍKOVÁ Markéta; HAUSNEROVÁ Jitka; HRSTKA Roman; OVESNÁ Petra; MOUKOVÁ Lucie; BRETOVÁ Petra; HLOBILKOVÁ Alice; KOBLÍŽKOVÁ Michaela; MÜNZOVÁ Dita; WEINBERGER Vít
• Year of publication: 2024
• Type: Conference abstract
• MU Faculty or unit: Faculty of Medicine
• Description: The prognostic significance of MMR deficiency (MMRd) has not been unequivocally established yet. Thus, treatment recommendations for newly diagnosed early MMRd EC patients do not differ from those with no specific molecular profile (NSMP). As a part of our research project concerning EC, this study aimed to assess the prognostic significance of MMR status and to compare clinical outcomes between MMRd and NSMP cohorts (defined as those with MMR-proficient and non-POLE ultra-mutated, TP53-wild type tumors).