Dávno překonaný, ale stále používaný - spotřeby fenobarbitalu v magistraliter přípravě

Title in English Obsolete for many years but still in use - consumption of phenobarbital in compounding pharmacies
Authors

TURJAP Miroslav PAILOVÁ Eva JUŘICA Jan

Year of publication 2024
Type Article in Periodical
Magazine / Source Česká a slovenská farmacie
MU Faculty or unit

Faculty of Medicine

Citation
Web https://csfarmacie.cz/artkey/csf-202401-0001_obsolete-for-many-years-but-still-in-use-consumption-of-phenobarbital-in-compounding-pharmacies.php
Keywords phenobarbital; individual compounding; obsolete mixtures; drug-drug interactions; drug safety
Description Phenobarbital was synthesized by the German organic chemist Emil Fischer in 1911. It is approved and marketed in the Czech Republic as an antiepileptic in tablet and injection form. Although phenobarbital as a hypnosedative has been outdated for decades, it is still available as a substance and used for the individual compounding of various obsolete mixtures. It is likely that prescribers are unaware of the risks associated with their use. The article presents a brief pharmacological profile of phenobarbital, lists the most often used mixtures, substance consumption and risks associated with its use.

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