Mutually potentiating effects of drugs elevating extracellular adenosine and granulocyte colony-stimulating factor on erythropoietic recovery following 5-fluorouracil-induced haematotoxicity in mice
| Authors | |
|---|---|
| Year of publication | 2000 |
| Type | Article in Periodical |
| Magazine / Source | Drug Development Research |
| MU Faculty or unit | |
| Citation | |
| Field | Oncology and hematology |
| Description | The ability of drugs increasing the level of extracellular adenosine (dipyridamole, AMP) to activate erythropoiesis (BFU-E in the bone marrow, reticulocytes and RBC in the peripheral blood) when given jointly with G-CSF is described. The observed additivity and synergism of G-CSF with elevated extracellular adenosine in terms of erythropoiesis is an interesting finding with potential implications in clinical practice. |
| Related projects: |