Úloha 5-HT1A receptoru při závislosti potkanů na metamfetamin
| Title in English | The role of 5-HT1A receptor in methamphetamine dependence in rats |
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| Authors | |
| Year of publication | 2001 |
| Type | Article in Periodical |
| Magazine / Source | Psychiatrie |
| MU Faculty or unit | |
| Citation | |
| Field | Pharmacology and pharmaceutical chemistry |
| Description | The effects of the 5-HT1A ligands on methamphetamine i.v. self-administration were ascertained in the present study. Experimental animals were pretreated with either 5-HT1A agonist 8-OH-DPAT or antagonist NAN-190. While non-significant (NS) increase of methamphetamine intake was observed after the pretreatment with 8-OH-DPAT, the pretreatment with NAN-190 caused NS decrease of methamphetamine intake which confirm the opposite effect of agonist and antagonist of 5-HT1A receptor. Our results suggest that the stimulation or blocking of 5-HT1A receptor subtype do not play very important role in the methamphetamine dependence. |
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