Methylenetetrahydrofolate reductase polymorphism, type II diabetes mellitus, coronary artery disease and essential hypertension in Czech population
| Authors | |
|---|---|
| Year of publication | 2001 |
| Type | Article in Periodical |
| Magazine / Source | Molecular Genetics and Metabolism |
| MU Faculty or unit | |
| Citation | |
| Field | Genetics and molecular biology |
| Keywords | gene; polymorphism; MTHFR; CAD; hypertension; diabetes |
| Description | Increased plasma concentration of homocysteine has been found in patients with coronary artery disease, essential hypertension and in patients with diabetic complications. The 677C/T methylenetetrahydrofolate reductase (MTHFR) gene polymorphism is related to the MTHFR enzyme activity and to the plasma homocysteine concentration. This study was designed to investigate an association of this polymorphism with CAD, EH and type II diabetes mellitus in Czech population. The C allele of the 677C/T MTHFR polymorphism was associated with type II diabetes mellitus in women, the T allele was associated with CAD only in normotensive subjects of Czech origin. |
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