The effect of sigma ligand haloperidol in guinea pig atrial preparation
| Authors | |
|---|---|
| Year of publication | 2002 |
| Type | Article in Proceedings |
| Conference | 78. Physiological Days. |
| MU Faculty or unit | |
| Citation | |
| Field | Physiology |
| Keywords | sigma receptor; haloperidol; modulation of contractility |
| Description | Sigma receptors ligands play a role in modulation of contractility in rat myocardium. The aim of the present study was to examine the effect of sigma ligand haloperidol in the multicellular guinea pig heart preparations. The effects of haloperidol on the amplitude of contraction and on the restitution of contractility were investigated. Marked positive inotropic effect previously described in rat cardiomyocytes (increase in the twitch amplitude ranging from 50 to 90 %, with maximal effect in the 5th minute of perfusion) was observed. The mechanical restitution pattern is not altered. Thus, the positive inotropic effect of sigma receptor ligand haloperidol was confirmed also in guinea pig atrial preparations. According to its effect on the mechanical restitution we can assume that it is mediated via increased cytoplasmatic Ca2+concentration. |