A newly identified single nucleotide polymorphism in the promoter of the matrix metalloproteinase-1 gene
| Authors | |
|---|---|
| Year of publication | 2002 |
| Type | Article in Periodical |
| Magazine / Source | Molecular and Cellular Probes |
| MU Faculty or unit | |
| Citation | |
| Field | Genetics and molecular biology |
| Keywords | single nucleotide polymorphism; matrix metalloproteinase |
| Description | Matrix metalloproteinase-1 (MMP-1) is a member of the matrix metalloproteinase enzyme family that degrades components of the extracellular matrix. Recent studies have demonstrated several polymorphic sites in the promoter of the MMP-1 gene. A newly identified single nucleotide polymorphism (SNP) at position -519 in the promoter region of the MMP-1 gene is reported. This polymorphism consists in a guanine to adenine substitution. A linkage between polymorphisms -519A/G and -1607 1G/2G was also studied. |
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