Association of Two Angiotensinogen Gene Polymorphisms (M235T and G(-6)A) with Chronic Heart Failure
| Authors | |
|---|---|
| Year of publication | 2003 |
| Type | Article in Periodical |
| Magazine / Source | International Journal of Cardiology |
| MU Faculty or unit | |
| Citation | |
| Field | Cardiovascular diseases incl. cardiosurgery |
| Keywords | Chronic heart failure; angiotensinogene gene; polymorphism |
| Description | The aim of the study was to focus on relationship between the angiotensinogen (AGT) gene polymorphisms, M235T and promoter G(-6)A, and chronic heart failure in the Czech population. 158 patients with chronic heart failure (functional class NYHA II-IV, ejection fraction <40% cardiothoracic index >50%) were compared with control group of 200 subjects of similar age and sex distribution, without any personal history of cardiovascular diseases. The AGT gene polymorphisms were detected by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods. No significant differences in distributions of AGT genotypes between patients with chronic heart failure (CHF) and controls were found. The differences in distributions of alleles in AGT M235T (Pa=0.02) and genotypes in AGT G(-6)A (Pg=0.017) were found within women groups. Within CHF patients the distribution of AGT G(-6)A genotypes was not consistent with Hardy-Weinberg equilibrium (P=0.0001). We found significant relative risk of CHF for GGMT genotype, OR=2.63 with 95% CI 1.39-4.95, Pcorr=0.01 (in man group OR=1.83, 95% CI 0.92-3.66, Pcorr=0.3; in woman group OR=15.5, 95% CI 1.86-129.42, Pcorr=0.008). We provide evidence of increased risk in subjects with GGMT variant of associated genotype of AGT gene for CHF, especially of fifteen-fold risk of this variant in women. |
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