Effect of methamphetamine and fluoxetine combination on behavioural activity in wistar albino rats
| Authors | |
|---|---|
| Year of publication | 2002 |
| Type | Article in Periodical |
| Magazine / Source | Bratislavské lekárské listy |
| MU Faculty or unit | |
| Citation | |
| Web | http://www.bmj.cz |
| Field | Pharmacology and pharmaceutical chemistry |
| Keywords | fluoxetine; methamphetamine; behaviour; rat |
| Description | Locomotor / exploratory behavioural changes were followed in Wistar rats pretreated with methamphetamine, fluoxetine or their combination. An "open field" (Acti-track, Panlab, Spain) was used as the tracking arena. Methamphetamine significantly increased all measured behavioural parameters while fluoxetine showed inhibitory effects. Pretreatment with combination of these drugs resulted in a more profound inhibition of locomotor activity than in fluoxetine given alone. |
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