Co-administration with cannabinoid receptro antagonist AM251 attenuates behavioural sensitization to methamphetamine antiaggressive effect in mice
| Authors | |
|---|---|
| Year of publication | 2003 |
| Type | Article in Periodical |
| Magazine / Source | Behavioural Pharmacology |
| MU Faculty or unit | |
| Citation | |
| Field | Pharmacology and pharmaceutical chemistry |
| Keywords | cannabinoid antagonist - AM251- methamphetamine - sensitiazation |
| Description | The sensitization to MET was clearly demonstrated in aggressive agonistic interactions while the pre-treatment with 5 MET doses of 1 mg/kg/day significantly potentiated the effects (inhibition of aggressive and disinhibition of locomotor activities measured) of all MET "challenge doses" (1 or 5 or 10 mg/kg) given after 5 days of withdrawal. In the same experimental design the cross-sensitization to MET was confirmed after the pre-treatment with 5 doses (0.5 mg/kg/day) of CAN, while in the present study, the co-administration of MET with cannabinoid receptor antagonist AM (0.5 mg/kg/day) suppressed the development of sensitization to MET antiaggressive effect but not to its stimulatory influence on locomotion. |
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