Pretreatment with cannabinoid receptor agonist and antagonist increases and decreases, respectively, sensitization to methamphetamine stimulation of mouse locomtor behaviour
| Authors | |
|---|---|
| Year of publication | 2003 |
| Type | Article in Periodical |
| Magazine / Source | Behavioural Pharmacology |
| MU Faculty or unit | |
| Citation | |
| Field | Pharmacology and pharmaceutical chemistry |
| Keywords | Behavioural sensitization; AM 251; methamphetamine; methanandamide; locomotion; mice |
| Description | In Experiment 1, psychostimulant methamphetamine and cannabinoid receptor agonist methanandamide were injected 7 days to two groups of mice either at the doses of 2.5 mg/kg/day or 0,5 mg/kg/day. On the day 8 all mice were given a "challenge dose" of methamphetamine 2.5 mg/kg to check a development of the hypothesised sensitization. In Experiment 2, methamphetamine and combined methamphetamine+selective CB1 receptor antagonist AM 251 treatments were injected 7 days to two groups of mice at the doses of either 2.5 mg/kg/day or 5 mg/kg/day. For the same reason as in Experiment 1 "challenge doses" of methamphetamine 2.5 mg/kg were given to all mice on the day 8. In Experiment 1, it has been shown that compared to control animals this procedure elicited in both methamphetamine and methanandamide pre-treated groups behavioural sensitisation: significant increase in distance run and fast movements and a significant decrease in resting time. Conversely, in Experiment 2, while in the group pre-treated with methamphetamine a significant behavioural sensitization was present the mice pre-treated with the combination of methamphetamine and AM 251 responded with significantly lower metamphetamine behavioural effect when compared to just methamphetamine sensitized animals. |
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