(R)-4-(4-Fluorophenyl)-1-[2-hydroxy-2-(3-methyl-1-benzofuran-2-yl)ethyl]piperazinium chloride propan-1-ol solvate

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Authors	KURFURST P. MAREK Jaromír VANČO J. CSÖLLEI J.
Year of publication	2004
Type	Article in Periodical
Magazine / Source	Acta Crystallographica Section C: Crystal Structure
MU Faculty or unit	Faculty of Science
Citation
Field	Pharmacology and pharmaceutical chemistry
Keywords	crystal structure; antihypertensive drug; heteroarylaminoethanole derivatives
Description	The title compound, C21H24FN2O2+.Cl-.C3H8O, is a potential drug designed as a hybrid compound with antihypertensive, antioxidant and -adrenolytic activity. The cation contains nearly planar benzofuran and fluorophenyl ring systems, as well as a piperazine ring adopting an almost perfect chair conformation. The benzofuran and piperazine moieties are connected by an ethyl chain, the moieties forming a dihedral angle of 163.12 (13)deg. In the crystal structure, ions and propanol solvent molecules are linked via N-HCl and O-HCl bonds into linear (010) chains.
Related projects:	Genomes and their functions