Impact of phenotyping CYP2D6 in psychiatry
| Authors | |
|---|---|
| Year of publication | 2004 |
| Type | Article in Periodical |
| Magazine / Source | Psychiatrie |
| MU Faculty or unit | |
| Citation | |
| Field | Psychiatry, sexuology |
| Keywords | phenotype; genotype; CYP2D6; clinical outcome |
| Description | The paper deal with comparison of distribution therapeutic efficacy and side effects of long term paroxetine treatment within 50 patients genotyped and phenotyped to determine their metabolic status. No variation in therapeutic efficacy and common adverse effects between subjects classified as poor metabilisers and extensice metabolisers were found. A significantkly higher rate of sexual dysfunction was recored among patients with a PM Phenotype. |
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