Polymorphisms of NMDA receptor, DRD2 receptor, GABA-A receptor and electrophysiologic variations found in BAEP and MLR in relation to tinnitus manifestation preliminary report.
| Authors | |
|---|---|
| Year of publication | 2004 |
| Type | Article in Proceedings |
| Conference | 5th European Congress of Oto-Rhino-Laryngology, Head and Neck Surgery, Rhodos, Hellas, Sept. 11-16, 2004 |
| MU Faculty or unit | |
| Citation | |
| Field | ORL, ophthalmology, stomatology |
| Keywords | tinnitus manifestation; genetic polymorphisms; NMDA receptor; DRD2 receptor; GABA-A receptor; BAEP; MLR |
| Description | Prospective study of 50 patients demonstrate the associations between tinnitus manifestation (multiple data acquired by help of a tinnitus questionnaire) emotional lability, and Taq I polymorphism of the DRD-2, three single nucleotide polymorphism in GRIN2A subunit of the NMDA receptor and CA repeat in GABRB3 subunit of the GABA-A receptor and changes of amplitude in BAEP and MLR response waveforms which can signalize the desinhibition of the central auditory pathways. The statistically significant correlation between the tinnitus score and the V/III amplitude ratios at intensities 110 (p=0,002) and 100 dB peSPL (p=0,025) has been found. The amplitude of Pa wave of MLR response correlates significantly with tinnitus score as well (p=0.006-0.05), There is also a statistically significant dependency between the V/III ratio and the amplitude of Pa wave (p=0,046 at 110 dB). The genetic analysis shows the difference of the tinnitus score according to genotypes of polymorphism GRIN2a MSP (less score in heterozygotes) which is statistically marginally significant (p=0,07), we have also found a difference of electrophysiological data according to the genotype in the polymorphism of GRIN2b PST (p=0,003). All tested polymorphisms have been verified to be consistent with the Hardy-Weinberg equilibrium. |