Analysis of the inducible nitric oxide synthase gene polymorphisms in Czech patients with atopic diseases

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Authors	IZAKOVIČOVÁ HOLLÁ Lydie STEJSKALOVÁ Andrea ZNOJIL Vladimír VAŠKŮ Anna
Year of publication	2006
Type	Article in Periodical
Magazine / Source	Clin Exp Allergy
MU Faculty or unit	Faculty of Informatics
Citation
Field	Epidemiology, infectious diseases and clinical immunology
Keywords	polymorphisms; asthma; atopic diseases; gene; iNOS
Description	Nitric oxide (NO) is an important mediator of physiologic processes in the airways; it plays a significant role in the regulation of the Th1/Th2 balance and contributes to the development of atopic diseases. In this stude we analyzed several polymorphisms mainly in the promoter region of the inducible nitric oxide synthase (NOS2, iNOS) gene and investigated their associations with asthma and/or atopic phenotypes.
Related projects:	Analýza polymorfizmů v genech pro syntetázu oxidu dusnatého (NOS) u atopického astmatu a jiných alergií v české populaci Genetické determinanty pro-/antioxidační rovnováhy v patogeneze respiračních nemocí