An immunohistochemical staining for activated p38 as a marker of non-neuronal cell changes following unilateral nerve injury
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| Year of publication | 2007 |
| Type | Appeared in Conference without Proceedings |
| MU Faculty or unit | |
| Citation | |
| Description | The p38 is a signaling molecule related to the MAP kinase group. By producing changes in gene transcription and posttranslational modifications participates in regulation of many cellular processes. In the present study we focused for immunohistochemical detection of activated p38 in the cervical and lumbar DRG of naive rats and rats following different types of peripheral nerve injury. Naive DRG showed only low levels immunofluorescence for p38. Following injury, increased p38-IF was found in the neurons and satellite cells of both cervical and lumbar DRG. Double staining with GS and ED1 suggested that at least parts of p38+ cells surrounding neurons are the SGC but not ED-1+ macrophages. Our results suggested that SGC are sense to circulating signal molecules produced during Wallerian degeneration and thus they participate in the nerve-injury signaling transduction pathways. In addition, the signaling mediated by SGC is spread to DRG not associated with nerve injury. |
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