Polymorhism of glutathione S-transferase M1, T1 and P1 in patients with reflux esophagitis and Barrett´s esophagus



Year of publication 2007
Type Article in Periodical
Magazine / Source Journal of Hum Genetics
MU Faculty or unit

Faculty of Medicine

Field Surgery incl. transplantology
Keywords GERD; GSTs; glutathione S-transferase; polymorphism; reflux esophagitis; gene
Description Glutathione S-transferase (GST) enzymes play an important role in cellular protection against oxidative stress and toxic foreign chemicals. So, we investigated the hypothesis that polymorphisms in genes for these detoxifying enzymes could influence susceptibility to RE and Barrett s esophagus. Methods: GSTM1, GSTT1 and GSTP1 loci were analyzed by PCR-based methods in 64 patients with RE (and additional group of 22 subjects with Barrett s esophagus as 4th grade of esophagitis) and 173 unrelated controls.Results: There were no significant differences in the distributions of GSTM1 and GSTT1 genotypes between controls and patients with RE or Barrett s esophagus. Similarly, frequencies of GSTP1 alleles were non-significantly different between control and reflux esophagitis groups. Conclusions: GSTP1 gene might be one of the risk factors associated with susceptibility to reflux esophagitis, especially to Barrett s esophagus.
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