Two Common Polymorphisms Within The Adiponectin Gene Are Associated With Food Preferences In Extremely Obese Czech Individuals
| Authors | |
|---|---|
| Year of publication | 2008 |
| Type | Article in Proceedings |
| Conference | 13th International SHR Symposium |
| MU Faculty or unit | |
| Citation | |
| Field | Genetics and molecular biology |
| Keywords | adiponectin; polymorphism; gene; obesity; food preferences |
| Description | Objectives: Considering the pivotal role of adiponectin in white adipose tissue metabolism and signaling, we assessed whether the 45T/G and 94T/G polymorphisms within the adiponectin gene influence the food preferences along with basic anthropometric characteristics in the Czech extremely obese population. Design and Methods: The total of 44 extremely obese subjects were enrolled in the study (BMI 46.03, SD 5.63; % of body fat 50.33, SD 5.13). Basic anthropometrical characteristics associated to obesity were measured and the food intake was monitored using 7- day record method. The polymerase chain reaction-restriction fragment length polymorphism (PCR based RFLP) method was used to establish the distribution of allele and genotype frequencies of the 45T/G (exon 2) and 94T/G (exon 2) polymorphisms. ELISA was used to determine plasma levels of leptin and leptin receptor. Results: Both polymorphisms studied were significantly associated with various body size measurements including weight, waist and hip circumference, percentage of body fat and body mass index. Furthermore, the 45T/G was linked to the plasma levels of leptin receptor (beta = -0.36, p = 0.002). A strong effect of 94T/G on the food preferences of the morbidly obese individuals was observed, the 94T/G GG genotypes being significantly associated with the increased protein and carbohydrates intake (beta = -3.2, p = 0.02, beta = -5.5, p = 0.002, respectively). Conclusions: The obtained data well fit into a framework for food intake regulation and could provide possible targets for further nutrigenomical research and intervention focused on the food preferences. |
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