Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vitro

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Authors	ANDERSSON Emma R. PRAKASH Nilima ČAJÁNEK Lukáš MININA Eleonora BRYJA Vítězslav BRYJOVÁ Lenka YAMAGUCHI Terry P. HALL Anita C. WURST Wolfgang ARENAS Ernest
Year of publication	2008
Type	Article in Periodical
Magazine / Source	PloS ONE
MU Faculty or unit	Faculty of Science
Citation
Field	Genetics and molecular biology
Keywords	Wnt5a deficient mouse, ventral midbrain, planar cell polarity
Description	Wnt5a is a morphogen that activates the Wnt/planar cell polarity (PCP) pathway and serves multiple functions during development. We hereby report a Wnt5a regulation of Wnt/PCP signaling in the DA lineage and provide evidence for multiple functions of Wnt5a in the VM in vivo, including the regulation of VM morphogenesis, DA progenitor cell division, and differentiation of NR4A2+ DA precursors.