Stanovení metylace genu pro O6-metylguanin DNA metyltransferasu (MGMT) u pacientů s glioblastomem - pilotní studie
| Title in English | Methylation Status of the MGMT Promoter in Patients with Glioblastoma - pilot study |
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| Authors | |
| Year of publication | 2008 |
| Type | Article in Periodical |
| Magazine / Source | Česká a Slovenská Neurologie a Neurochirurgie |
| MU Faculty or unit | |
| Citation | |
| Field | Neurology, neurosurgery, neurosciences |
| Keywords | MGMT; glioblastoma; therapy |
| Description | Pigenetic silencing of the mgmt (O6-methylguanine-DNA methyltransferase)gene by promoter methylation has been associated with longer overall survival in patients with glioblastoma who, in addition to radiotherapy, received alkylating chemotherapy with carmustineor temozolomide. We found that MGMT promoter methylation is associated with a favorable outcome after temozolomide chemotherapy in patients with newly diagnosed glioblastoma. Our data suggest that the methylation status of the MGMTpromoter may have prognostic value and, in addition, may be a clinically relevant predictor of benefit from temozolomide chemotherapy |