Alternation of retinoic acid induced neural differentiation of P19 embryonal carcinoma cells by reduction of reactive oxygen species intracellular production

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Authors	KONOPKA Roman KUBALA Lukáš LOJEK Antonín PACHERNÍK Jiří
Year of publication	2008
Type	Article in Periodical
Magazine / Source	NEUROENDOCRINOLOGY LETTERS
MU Faculty or unit	Faculty of Science
Citation
Web	http://www.ncbi.nlm.nih.gov/pubmed/18987612?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
Field	Physiology
Keywords	embryonal carcinoma cells; neural differentiation; redox status; antioxidants
Description	Intracellularly generated reactive oxygen species (ROS) are thought to modulate redox sensitive signaling pathways and thus regulate cell physiology including proliferation and differentiation. However, the role of ROS in neuronal differentiation of embryonic pluripotent cells is unknown. For this reason, the modification of retinoic acid (RA) induced neuronal differentiation of mouse embryonal carcinoma cells P19 by selected ROS scavengers and flavoprotein inhibitor was evaluated.
Related projects:	Mechanismy řídící neurální diferenciaci myších embryonálních kmenových buněk in vitro