CXXC5 is a novel BMP4-regulated modulator of Wnt-signaling in neural stem cells

Warning

This publication doesn't include Faculty of Medicine. It includes Faculty of Science. Official publication website can be found on muni.cz.

Authors	ANDERSSON Therese SÖDERSTEN Erik DUCKWORTH K. Joshua CASCANTE Anna FRITZ Nicolas SACCHETTI Paola ČERVENKA Igor BRYJA Vítězslav HERMANSON Ola
Year of publication	2009
Type	Article in Periodical
Magazine / Source	Journal of Biological Chemistry
MU Faculty or unit	Faculty of Science
Citation
Field	Genetics and molecular biology
Keywords	Wnt signalling; CXXC5; neural stem cells
Description	In a screen designed to identify novel targets of BMP4 signaling in telencephalic neural stem cells, we found that the levels of the previously uncharacterized factor CXXC5 were reproducibly up-regulated after BMP4 stimulation. We demonstrate that CXXC5 can interact with the Wnt-signaling intermediate Dishevelled and attenuate Wnt signalling. We conclude that CXXC5 is a BMP4-induced inhibitor of Wnt signaling in neural progenitors.
Related projects:	Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies