EXPRESE TRANSKRIPČNÍHO FAKTORU NFAT1 ZVYŠUJE CITLIVOST MONOBLASTŮ BM2 KE KYSELINĚ RETINOVÉ
| Title in English | Overexpression of transcription factor NFAT1 increases sensitivity of monoblasts BM2 to retinoic acid |
|---|---|
| Authors | |
| Year of publication | 2009 |
| Type | Article in Proceedings |
| Conference | XIII. Setkání biochemiků a molekulárních biologů |
| MU Faculty or unit | |
| Citation | |
| Field | Genetics and molecular biology |
| Keywords | differentiation; NFAT1; retinoic acid; monoblast |
| Description | NFAT is a nuclear protein that undergoes activation in myelomonoctic cells and plays a key role in regulation of osteoclastogenesis. In this study we showed that BM2 monoblasts with increased level of NFAT expression become more sensitive to retinoic acid. These cells respond to the retinoic acid treatment by growth arrest, changes in cellular morphology, increased phagocytic activity and production of oxygen radicals. |
| Related projects: |