Efficacious but insidious: A retrospective analysis of fludarabine induced myelotoxicity using long term culture initiating cells in 100 follicular lymphoma patients
| Authors | |
|---|---|
| Year of publication | 2009 |
| Type | Article in Periodical |
| Magazine / Source | Experimental Hematology |
| MU Faculty or unit | |
| Citation | |
| Field | Oncology and hematology |
| Keywords | NON-HODGKIN-LYMPHOMA; CHRONIC LYMPHOCYTIC-LEUKEMIA; HEMATOPOIETIC STEM-CELLS; BLOOD PROGENITOR CELLS; ACUTE MYELOID-LEUKEMIA; PREVIOUSLY UNTREATED PATIENTS; IV INDOLENT LYMPHOMA; HIGH-DOSE THERAPY; BONE-MARROW; PHASE-II |
| Description | Fludarabine has been recognized as effective treatment in patients with follicular lymphoma (FL), but can induce myelotoxicity of unknown mechanism. Fludarabine and procarbazine have a dramatic influence, especially on the most immature hematopoietic cells, mirrored in reduced numbers of LTC-IC. This finding is consistent with clinical observations (poor mobilization after fludarabine) and offers an insight into the mechanism of fludarabine-induced myelotoxicity. |
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