Hygienická hypotéza a výskyt alergií u tříletých dětí. Výsledky studie Elspac

Title in English The hygiene hypothesis and allergic diseases among children aged 3 years. Elspac study results

HRUBÁ Drahoslava KUKLA Lubomír TYRLÍK Mojmír MATĚJOVÁ Halina

Year of publication 2009
Type Article in Periodical
Magazine / Source Hygiena : časopis pro ochranu a podporu zdraví
MU Faculty or unit

Faculty of Medicine

Field Hygiene
Keywords infants allergy morbidity hygiene hypothesis
Description The Hygiene hypothesis proposes an explanation for the rising prevalence of allergic diseases through improved care early in life.Reduced exposure to infectious agents can deprive the immune system of maturation and support the survival of the fetal-typeTh1/Th2 ratio. In the EPSLAC study, children aged 3 years were divided into3 groups according to absence / presebce of allergic diseases( atopy, urtica. hay fever, asthma, others): non-allergic(NA), monoallergic (A1), polyallergic (A2+). possible risk factors were evaluated : living in a large family, brest feeding, exposure to smoking, postnatal morbidity, vaccination, contact with animals, attending day care. Statistical significance was tested by the SPSS programme. Our results did not confirm the hygiene hypothesis : thy family size, contact with animals, attending, day care, exposure to passive smoking, length of breast feeding and vaccination were similarly prevalent in all child groups. On the other hand, respiratpry morbidity and use of antibiotics were significantly higher in the groups of allergic children, both after birth, and during their 2nd and 3rd years of age.
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