Association of A1166C Polymorphism in AT(1) Receptor Gene with Baroreflex Sensitivity
| Authors | |
|---|---|
| Year of publication | 2010 |
| Type | Article in Periodical |
| Magazine / Source | Physiological Research |
| MU Faculty or unit | |
| Citation | |
| Web | http://apps.isiknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=1&SID=X1EL3PjGbGJMeHdJIdi&page=1&doc=2 |
| Field | Physiology |
| Keywords | baroreflex sensitivity; angiotensin II type 1 receptor; polymorphism; spectral analysis |
| Description | Diminished baroreflex sensitivity is connected with hypertension, cardiac failure and presents a risk factor for sudden cardiac death in patients after myocardial infarction. The aim of this study was to evaluate the association of A1166C polymorphism in angiotensin II type 1 receptor (AT(1)R) gene with baroreflex sensitivity in man. We found a significant association of A1166C polymorphism in AT(1) receptor gene with baroreflex sensitivity. Homozygosity for the less frequent allele was associated with decreased baroreflex sensitivity. |
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