Relation between TGF-beta1 levels in cerebrospinal fluid and ETV outcome in premature newborns with posthemorrhagic hydrocephalus. Relation between TGF-ß1 levels in cerebrospinal fluid and ETV outcome
| Authors | |
|---|---|
| Year of publication | 2010 |
| Type | Article in Periodical |
| Magazine / Source | Childs Nerv Syst |
| MU Faculty or unit | |
| Citation | |
| Field | Neurology, neurosurgery, neurosciences |
| Keywords | Posthemorrhagic hydrocephalus Endoscopic third ventriculostomy Transforming growth factor beta1 Premature infants |
| Description | Though pathophysiology of PHH is more complicated and TGF-beta1 is not the only one to play a role in it, we have documented in our study that TGF-beta1 level in CSF collected in the beginning of temporary treatment of PHH correlates with failure of CSF resorption. In our study, in 62.5% of patients with proof of obstruction, hyporesorptive component was present. Overall, ETV success rate in therapy of obstructive PHH 37.5% in our study. We have proven that premature newborns with lower TGF-beta1 level and proof of obstructive HDC on MRI have significantly higer success rate of endoscopic treatment. In our study, ETV success rate was 100% in this group. Our results show that TGF-beta1 may influence succes rate of ETV in treatment of PHH, and based on its levels, it is possible to choose patients with purely obstructive hydrocephalus. |