Difúzní velkobuněčný B-lymfom
| Title in English | Diffuse large B-cell lymphoma |
|---|---|
| Authors | |
| Year of publication | 2011 |
| Type | Article in Periodical |
| Magazine / Source | Postgraduální medicína |
| MU Faculty or unit | |
| Citation | |
| Field | Oncology and hematology |
| Keywords | anthracycline; diffuse large B-cell; lymphoma; immunochemotherapy; prognosis |
| Description | Diffuse large B-cell lymphoma (DLBCL) represents a heterogenous mixture of mature B-lymphoproliferative disorders, histologically composed of large transformed B cells with diffuse growth pattern. Overall it is the most common type of all non-Hodgkin lymphomas. According to the WHO 2008 classification, it is divided into 5 main subtypes, from which diffuse large B-cell lymphoma not otherwise specified is the most frequent one. Primary mediastinal B-cell lymphoma, formerly classified into DLBCL, is a separate entity today. The prognosis of DLBCL can be estimated with International Prognostic Index (IPI) or age-adjusted IPI in younger patients. The standard of care is a combination of anthracycline-based chemotherapy and anti-CD20 monoclonal antibody rituximab. Approximately 70% of DLBCL patients can be cured with this approach. |