Type I iodothyronine 5’-deiodinase mRNA and activity is increased in adipose tissue of obese subjects

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Authors	ORTEGA F. J. JÍLKOVÁ Z. M. MORENO-NAVARRETE J. M. PAVELKA Stanislav RODRIGUEZ-HERMOSA J. I. KOPECKÝ Jan FERNÁNDEZ-REAL J. M.
Year of publication	2012
Type	Article in Periodical
Magazine / Source	International Journal of Obesity
MU Faculty or unit	Central European Institute of Technology
Citation
Web	http://www.nature.com/ijo/journal/v36/n2/full/ijo2011101a.html
Doi	http://dx.doi.org/10.1038/ijo.2011.101
Field	Endocrinology, diabetology, metabolism, nutrition
Keywords	Adipose tissue; thyroid hormones; deiodinases; tissue expression; enzyme activity
Description	Expression of the genes for type I iodothyronine 5'-deiodinase (D1), leptin (LEP) and stearoyl-CoA desaturase 1 (SCD-1) was evaluated in omental (OM) and subcutaneous (SC) fat using a cohort of 70 humans. Activities of iodothyronine deiodinases (D1, D2 and D3) were assessed in a randomly selected subpopulation of 19 subjects.
Related projects:	Proteins in metabolism and interaction of organisms with the environment