Predicting non-sentinel lymph node status after positive sentinel biopsy in breast cancer: what model performs the best in a czech population?
| Authors | |
|---|---|
| Year of publication | 2009 |
| Type | Article in Periodical |
| Magazine / Source | PATHOLOGY & ONCOLOGY RESEARCH |
| MU Faculty or unit | |
| Citation | |
| Field | Oncology and hematology |
| Keywords | Breast cancer; Lymphatic metastasis; Nomogram; Prediction; Sentinel lymph node biopsy; Tumor cells; Isolated |
| Description | Several models have previously been proposed to predict the probability of non-sentinel lymph node metastases after a positive sentinel lymph node biopsy in breast cancer. The aim of this study was to assess the accuracy of two previously published nomograms and to develop an alternative model with the best predictive accuracy in a Czech population. In the basic population of 330 SLN-positive Czech patients, the accuracy of the MSKCC and the Stanford nomograms was tested by the area under the receiver operating characteristics curve. A new model was proposed according to the results of multivariate analysis of relevant clinicopathologic variables. The new model was validated in an independent test population from Hungary (383 patients). In the basic population, the previously published nomograms showed only limited accuracy. The developed MOU nomogram proved more suitable for the basic population, such as for another independent population from a mid-European country. |