Androgen Depletion Induces Senescence in Prostate Cancer Cells through Down-regulation of Skp2

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Authors	PERNICOVÁ Zuzana SLÁBÁKOVÁ Eva KHARAISHVILI Gvantsa BOUCHAL Jan KRÁL Milan KUNICKÁ Zuzana MACHALA Miroslav KOZUBÍK Alois SOUČEK Karel
Year of publication	2011
Type	Article in Periodical
Magazine / Source	Neoplasia
MU Faculty or unit	Central European Institute of Technology
Citation
Web	http://www.neoplasia.com/pdf/manuscript/v13i06/neo11182.pdf
Doi	http://dx.doi.org/10.1593/neo.11182
Field	Genetics and molecular biology
Keywords	CELLULAR SENESCENCE; IN-VIVO; DEPRIVATION THERAPY; SECRETORY PHENOTYPE; EPITHELIAL-CELLS; TUMORIGENESIS; FIBROBLASTS; EXPRESSION; GROWTH; PROLIFERATION
Description	Although the induction of senescence in cancer cells is a potent mechanism of tumor suppression, senescent cells remain metabolically active and may secrete a broad spectrum of factors that promote tumorigenicity in neighboring malignant cells.We propose that ADT may contribute to the development of androgen-independent prostate cancer through modulation of the tissue microenvironment by senescent cells.
Related projects:	Molecular basis of cell and tissue regulations Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies