Analýza souboru pacientů s onemocněním vyvolaným toxinem Clostridium difficile hospitalizovaných na Klinice infekčních chorob v Brně v letech 2007-2010
| Title in English | Analysis of patients with Clostridium difficile infection hospitalized at Department of Infectious diseases in Brno in 2007-2010 |
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| Authors | |
| Year of publication | 2011 |
| Type | Article in Periodical |
| Magazine / Source | Klinická mikrobiologie a infekční lékařství. |
| MU Faculty or unit | |
| Citation | |
| Field | Epidemiology, infectious diseases and clinical immunology |
| Keywords | Clostridium difficile infection; antibiotic-associated diarrhoea; treatment |
| Description | Background: Describe a set of patients hospitalized at the Clinic of infectious diseases (KICH) the University hospital Brno (FNB) with Clostridium difficile infection (CDI), interpret clinical and epidemilogical data, determine the risk factors for the disease and its complications. Material and methods: A retrospective study of 284 patients with proven diagnosis of Clostridium difficile infection hospitalized in the period from 1.1.2007 to 31.12.2010. Epidemiological, clinical and laboratory data were collected from the clinical documentation. Results: In a group of 284 patients, having mean age of 73,2 years, 38,03% were men. Risk factors for developing CDI include use of antibiotics in the previous 8 weeks (89,08% of patients), age over 65 years (77,46%), hospitalisation in the previous 4 weeks (65,49%), use of proton pump inhibitors (41,90%). Reccurence was noted in 89 (31,34%) cases, intensive care required 66 (23,24%) patients, during the hospitalisation died 50 (14,61%) patients. Isolates of C. difficile from the stool of 4 patients were sent for ribotyping and have been identified as ribotype 0176. Conclusions: Number of CDI at KICH increases in the recent years, it copies the worldwide trend of this disease. Study confirms disease risk factors described in the literature. The disease is associated with a high percentage of relapses and complications. |