doc. MVDr. Aleš Hampl, CSc.
Department head, Department of Histology and Embryology
| phone: | +420 549 49 3514 |
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Cell and Regenerative Medicine
Department of Histology and Embryology
Key Topics:
- Biology of stem and progenitor cells, application in biomedicine
- Aspects of pluripotent stem cells with a main focus on genomic stability
- Modeling neural differentiation in vitro using human pluripotent stem cells
- Human pluripotent stem cells derived retinal organoids with a special focus on non-coding microRNA and rare disease modeling
- Translational aspects of stem cells and their derivatives, including the safety issues related to SC stability and developing recommendations for GMP production and quality control of ATMP
- Development of 3D cell culture platforms, tools to study SC differentiation and communication, methods for bioprinting of SC in hydrogels, and microfluidic systems for long-term 3D culture and studying ex vivo morphogenesis
Department of Burns and Plastic Surgery
Key Topics:
- Biomaterials and biotechnology
- Inhalation injury
- Toxic epidermal necrolysis
- Infection control and antimicrobials
Monika Pávková Goldbergová Group: Metals in Medicine
Key Topics:
- Interactions between living tissues/cells and implanted metal components
- Behaviour of advanced NiTi and titanium based alloys in cell culture environments and in vivo models
- Changes in cellular protein expression, mRNA and cellular metabolism
- Modification of the material surface in connection with the improvement of the biocompatibility of the material
prof. RNDr. Monika Pávková Goldbergová, Ph.D.
Head of the research group, Monika Pávková Goldbergová Research Group: Metals in Medicine
| phone: | +420 549 49 3859 |
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Petr Vaňhara Group: Tissue Plasticity and Regeneration
Key Topics:
- Tissue microenvironment promotes changes cell and lineage specifications in normal and cancer tissues
- Individual integrated cell stress response affect cancer and stem cell phenotypes
- Molecular machinery of endoplasmic reticulum and unfolded protein response alters tissue functions and repair
doc. RNDr. Petr Vaňhara, Ph.D.
Department vice-head, Department of Histology and Embryology
Head of the research group, Petr Vaňhara Research Group: Tissue plasticity and regeneration
| phone: | +420 549 49 7780 |
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Tomáš Bárta Group
Key Topics:
- Molecular mechanisms underlying cell fate switch during reprogramming with special focus on non-coding microRNA molecules.
- Molecular mechanisms of differentiation of human pluripotent stem cells into retinal tissues.
- How light irradiation regulates development of human retina
- How light irradiation regulates circadian rhythms/molecular clock pathways
Mgr. Tomáš Bárta, Ph.D.
Head of the research group, Tomáš Bárta Research Group: Stem Cell Biology and Vision Research
| phone: | +420 549 49 6052 |
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Zuzana Koledová Group: Mechanisms of Epithelial Morphogenesis
Key Topics:
- Epithelial morphogenesis, homeostasis, and deregulation of which can lead to developmental defects and cancer.
- Interplay of biochemical and mechanical signals in shaping epithelial sheets to functional structures.
- Regulation of epithelial branching morphogenesis of the paradigmatic branched organ unique to mammals, the mammary gland
- Advanced 3D cell culture models and organoids, state-of-the-art imaging techniques, genetic mouse models and mathematical modelling
