doc. MVDr. Aleš Hampl, CSc.
přednosta ústavu – Ústav histologie a embryologie
| telefon: | 549 49 3514 |
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Cell and Regenerative Medicine
Department of Histology and Embryology
Key Topics:
- Biology of stem and progenitor cells, application in biomedicine
- Aspects of pluripotent stem cells with a main focus on genomic stability
- Modeling neural differentiation in vitro using human pluripotent stem cells
- Human pluripotent stem cells derived retinal organoids with a special focus on non-coding microRNA and rare disease modeling
- Translational aspects of stem cells and their derivatives, including the safety issues related to SC stability and developing recommendations for GMP production and quality control of ATMP
- Development of 3D cell culture platforms, tools to study SC differentiation and communication, methods for bioprinting of SC in hydrogels, and microfluidic systems for long-term 3D culture and studying ex vivo morphogenesis
Department of Burns and Plastic Surgery
Key Topics:
- Biomaterials and biotechnology
- Inhalation injury
- Toxic epidermal necrolysis
- Infection control and antimicrobials
Monika Pávková Goldbergová Group: Metals in Medicine
Key Topics:
- Interactions between living tissues/cells and implanted metal components
- Behaviour of advanced NiTi and titanium based alloys in cell culture environments and in vivo models
- Changes in cellular protein expression, mRNA and cellular metabolism
- Modification of the material surface in connection with the improvement of the biocompatibility of the material
prof. RNDr. Monika Pávková Goldbergová, Ph.D.
vedoucí výzkumné skupiny – Výzkumná skupina Moniky Pávkové Goldbergové: Kovy v medicíně
| telefon: | 549 49 3859 |
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Petr Vaňhara Group: Tissue Plasticity and Regeneration
Key Topics:
- Tissue microenvironment promotes changes cell and lineage specifications in normal and cancer tissues
- Individual integrated cell stress response affect cancer and stem cell phenotypes
- Molecular machinery of endoplasmic reticulum and unfolded protein response alters tissue functions and repair
doc. RNDr. Petr Vaňhara, Ph.D.
zástupce přednosty ústavu – Ústav histologie a embryologie
vedoucí výzkumné skupiny – Výzkumná skupina Petra Vaňhary: Tissue plasticity and regeneration
| telefon: | 549 49 7780 |
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Tomáš Bárta Group
Key Topics:
- Molecular mechanisms underlying cell fate switch during reprogramming with special focus on non-coding microRNA molecules.
- Molecular mechanisms of differentiation of human pluripotent stem cells into retinal tissues.
- How light irradiation regulates development of human retina
- How light irradiation regulates circadian rhythms/molecular clock pathways
Mgr. Tomáš Bárta, Ph.D.
vedoucí výzkumné skupiny – Výzkumná skupina Tomáše Bárty: Stem Cell Biology and Vision Research
| telefon: | 549 49 6052 |
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Zuzana Koledová Group: Mechanisms of Epithelial Morphogenesis
Key Topics:
- Epithelial morphogenesis, homeostasis, and deregulation of which can lead to developmental defects and cancer.
- Interplay of biochemical and mechanical signals in shaping epithelial sheets to functional structures.
- Regulation of epithelial branching morphogenesis of the paradigmatic branched organ unique to mammals, the mammary gland
- Advanced 3D cell culture models and organoids, state-of-the-art imaging techniques, genetic mouse models and mathematical modelling
