Project information
Molecular pathophysiology of multigene diseases
- Project Identification
- MSM 141100002
- Project Period
- 1/1999 - 1/2004
- Investor / Pogramme / Project type
-
Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Faculty of Medicine
- Keywords
- Multigenic disease, essential hypertension, ischemia, atopy, diabetes type II, late complications of diabetes, matrix metalloproteinase, gene polymorphism, remodeling, gene derepression, case-control study, PCR, SSCP, RFLP, sequencing.
Effects of allelic variability of the genes coding for matrix metalloproteinases (MMPs) on the etiopathogenesis of the essential hypertension, myocardial ischemia, atopic diseases, and late complications of diabetes II will be studied. Genotyping of individuals will be performed using molecular biological methods, especially PCR, SSCP, RFLP, and/or direct sequencing. Groups of diseased persons will be compared with the appropriate control groups (case-control study).
Publications
Total number of publications: 233
1997
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Different onset of nucleolar activation in endocardial endo helial cells and cardiomyocytes following pressure overload in rat heart
Journal of Molecular and Cellular Cardiology, year: 1997, volume: 29, edition: 9
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Induction of cell-cycle inhibitor p21 in rat ventricular myocytes during early postnatal transition from hyperplasia to hypertrophy
Physiological Research, year: 1997, volume: 46, edition: 3
1996
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Angiotensin I-converting enzyme (ACE) polymorphism and AB0 blood groups as factors codetermining plasma ACE activity
Experimental Hematology, year: 1996, volume: 24, edition: 7