From dysfunction of the blood-cerebrospinal fluid barrier to neuroinflammation and Alzheimer's disease, An integrative study

Project Identification
MUNI/11/SUP/11/2022
Project Period
1/2022 - 12/2022
Investor / Pogramme / Project type
Masaryk University
MU Faculty or unit
Faculty of Medicine

Alzheimer’s disease is a neurodegenerative disorder, and Its pathological hallmarks include amyloid-β deposition and tau plaque formation. The choroid plexus forming the blood-cerebrospinal fluid barrier, crucial for brain homeostasis, plays a significant role in the clearance of amyloid-β. During Alzheimer’s disease, insufficient clearance of amyloid-β and enhanced inflammatory changes in the choroid plexus and cerebrospinal fluid, are observed. Despite its clinical importance, our knowledge of the role of the choroid plexus in the onset and progression of Alzheimer’s disease remains rather limited. We intend to carry out an integrative approach-based study to better understand the underlying mechanisms by which choroid plexus responds to the amyloid-β toxicity.

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