Proteomic composition of phosphatidylserine-positive extracellular vesicles released during cell death as a marker for personalized medicine.

Project Identification
Project Period
1/2023 - 12/2023
Investor / Pogramme / Project type
Masaryk University
MU Faculty or unit
Faculty of Medicine

Extracellular vesicles (EVs) represent a heterogeneous group of membrane-bounded vesicles released by all cells. Since EVs contain thousands of different cellular proteins and a large number of nucleic acids, which together represent a kind of imprint of the parent cell, a wide range of potential applications is offered. Also, cells undergoing the process of cell death release EVs into their surroundings, which not only affect surrounding and relatively distant cells with different effects but also carry specific information about the type of cell death that is taking place in the dying cells. Given the difficulty of specifically and sensitively detecting different types of cell death in vivo, EVs thus offer a valuable tool to monitor the response of a cell population to therapy using specific molecules.

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Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.

Sustainable Development Goal No.  3 – Good health and well-being Sustainable Development Goal No.  4 – Quality education

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