Antifosfolipidový syndrom – klinické projevy, diagnostika a možnosti léčby, komplikace
| Title in English | Antiphospholipid syndrome - clinical manifestations, evaluation, therapeutic options, complications |
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| Authors | |
| Year of publication | 2016 |
| Type | Article in Periodical |
| Magazine / Source | Remedia |
| MU Faculty or unit | |
| Citation | |
| Field | Oncology and hematology |
| Keywords | antiphospholipid syndrome; clinical manifestation; diagnosis; treatment; complications |
| Description | Antiphospholipid syndrome represents one of the most important thrombophilic conditions. It is defined by simultaneous presence of clinical manifestation, i.e. thrombosis or reproductive failure, and detection of antiphospholipid antibodies. Nevertheless, it can be also accompanied by wide spectrum of so called non-criteria manifestations like heart valve disease, nephropathy, thrombocytopenia, skin involvement, and others. Diagnosis of the antiphospholipid syndrome is confirmed by fulfilling of diagnostic criteria, which are defined by international consensus. The main therapeutic approach is the antithrombotic treatment. However, immunomodulatory drugs can play an important role in some situations, especially in non-criteria manifestations. The most serious complication of this syndrome is catastrophic antiphospholipid syndrome. This life treating condition should be kept in mind in patients with antiphospholipid antibodies, as it needs early diagnosis and intensive treatment. |