Light-Activated Peptide-Based Materials for Sutureless Wound Closure

Authors

MCTIERNAN CD CORTES DC LAZURKO C AMRANI S ROSALES-ROJAS R ZUNIGA-BUSTOS M SEDLÁKOVÁ Veronika POBLETE H STAMPLECOSKIE K SUURONEN EJ ALARCON EI

Year of publication 2019
Type Article in Periodical
Magazine / Source ACS APPLIED MATERIALS & INTERFACES
Citation
Doi http://dx.doi.org/10.1021/acsami.9b18891
Keywords tissue photobonding; Rose Bengal; collagen; peptide; wound healing
Description Using chemically modified extracellular matrix proteins, such as collagen, in combination with light for tissue bonding reduces inflammation and minimizes scarring. However, full length animal or recombinant human collagen proteins are difficult to isolate/produce. Thus, short biomimetic collagen peptides with properties equivalent to collagen at both structural and functional levels may be ideal building blocks for the development of remotely triggered adhesives and fillers. In this work, the conjugation of self-assembling collagen-like peptides to acrylate functionalized polyethylene glycol units yielded adhesive filler materials activated by visible light through the incorporation of a photosensitizer. When tested in a murine skin wound model, the photoactivated adhesives showed reduced scar formation and promoted epithelial regeneration.

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