Circulating cytokine pattern and factors describing rheumatoid arthritis: IL-15 as one of the biomarkers for RA?
| Authors | |
|---|---|
| Year of publication | 2012 |
| Type | Article in Periodical |
| Magazine / Source | Biomarkers |
| MU Faculty or unit | |
| Citation | |
| Doi | http://dx.doi.org/10.3109/1354750X.2012.719036 |
| Field | Genetics and molecular biology |
| Keywords | rheumatoid arthritis; cytokine; interleukin; circulating level |
| Attached files | |
| Description | The aim of study was to examine relationship among levels of cytokines (IL-6, IL-13, IL-15, TNF-alpha) and chemokine (IL-8), production of autoantibodies, radiographic progression, and factors describing rheumatoid arthritis (RA). A total of 156 RA patients according to ACR criteria, and 55 control subjects were recruited into study. We observed higher levels of IL-15 within RA patients compared to healthy controls. Correlations among cytokine levels and the measures of rheumatoid factors, anti-CCP, measures of disease activity, and radiographic progression were observed. We conclude that IL-15 level in circulation could serve as one of the biomarkers for RA detection. |