Interleukin-17 gene variability and IL-17 plasma levels in patients with chronic periodontitis

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KAŠTOVSKÝ Jakub BOŘILOVÁ LINHARTOVÁ Petra LUČANOVÁ Světlana BÁRTOVÁ Jiřina POSKEROVÁ Hana VOKURKA Jan FASSMANN Antonín KAŇKOVÁ Kateřina IZAKOVIČOVÁ HOLLÁ Lydie

Year of publication 2015
Type Appeared in Conference without Proceedings
Citation
Description Periodontitis is a chronic infection characterized by a progressive inflammatory response to bacteria in dental plaque, which finally results in periodontal tissue destruction and tooth loss. Interleukin-17 (also known as IL-17A) plays a role in innate immunity, protection against pathogens and contributes to the pathogenesis of chronic periodontitis (CP). The aims of this study were to analyse IL-17A -197A/G (rs2275913) and IL-17F +7488C/T (His161Arg, rs763780) gene polymorphisms in patients with CP, and determine their possible associations with IL-17 production and occurrence of periodontopathic bacteria in CP patients.Our findings demonstrated the functional relevance of the IL-17A polymorphism, where A allele were associated with higher IL-17 secretion and with occurrence of “red complex” bacteria in patients with CP.
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