Interleukin-17 gene variability and IL-17 plasma levels in patients with chronic periodontitis

Logo poskytovatele
Autoři

KAŠTOVSKÝ Jakub BOŘILOVÁ LINHARTOVÁ Petra LUČANOVÁ Světlana BÁRTOVÁ Jiřina POSKEROVÁ Hana VOKURKA Jan FASSMANN Antonín KAŇKOVÁ Kateřina IZAKOVIČOVÁ HOLLÁ Lydie

Rok publikování 2015
Druh Další prezentace na konferencích
Citace
Popis Periodontitis is a chronic infection characterized by a progressive inflammatory response to bacteria in dental plaque, which finally results in periodontal tissue destruction and tooth loss. Interleukin-17 (also known as IL-17A) plays a role in innate immunity, protection against pathogens and contributes to the pathogenesis of chronic periodontitis (CP). The aims of this study were to analyse IL-17A -197A/G (rs2275913) and IL-17F +7488C/T (His161Arg, rs763780) gene polymorphisms in patients with CP, and determine their possible associations with IL-17 production and occurrence of periodontopathic bacteria in CP patients.Our findings demonstrated the functional relevance of the IL-17A polymorphism, where A allele were associated with higher IL-17 secretion and with occurrence of “red complex” bacteria in patients with CP.
Související projekty:

Používáte starou verzi internetového prohlížeče. Doporučujeme aktualizovat Váš prohlížeč na nejnovější verzi.

Další info