Duální opioidní analgezie

Title in English Dual opioid analgesia
Authors

JUŘICA Jan

Year of publication 2022
Type Article in Periodical
Magazine / Source Praktické lékárenství
MU Faculty or unit

Faculty of Medicine

Citation
Web https://www.praktickelekarenstvi.cz/artkey/lek-202201-0007_dualni_opioidni_analgezie.php
Doi http://dx.doi.org/10.36290/lek.2022.007
Keywords opioid receptors; pain management; opioids; dual opioid analgesia
Description Current opioid analgesics are agonists or partial agonists of the opioid receptors µ, ?, ?, and ORL1 (MOPr, DOPr, KOPr, and NOPr.) The combination of agonists and partial agonists or two full agonists with different receptor affinities should theoretically reduce the potential of maximal analgesic effect. However, in clinical practice, these combinations are particularly effective in increasing analgesic efficacy, better tolerability, better control of pain intensity during the day, and delaying tolerance to the analgesic effect. The article provides an overview of the current state of knowledge about dual opioid analgesia and pharmacological arguments supporting the rationality of these combinations. Nevertheless, it should be emphasized that the combination of opioids is not recommended practice but rather an alternative approach in the case of failure of the standard treatment accordingly to the current clinical guidelines
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