Pulzový tlak a riziko kardiovaskulárních nemocí

Title in English Pulse pressure and risk of cardiovascular diseases.


Year of publication 2003
Type Article in Periodical
Magazine / Source Kardiologická revue
MU Faculty or unit

Faculty of Medicine

Field Cardiovascular diseases incl. cardiosurgery
Keywords Pulse pressure - great arteries compliance - velocity of pulse wave - betaxolol
Description The pulse pressure means the difference between systolic and diastolic blood pressure. Physiologically it increases during the life, both systolic and diastolic values. About in 60 years the systolic pressure increases forth, but the diastolic one begins to decrease, so that the pulse pressure increases. The causes are the decrease of great arteries compliance and increase of the pulse wave velocity. The risk factors of pulse pressure increase include age, diabetes mellitus, obesity, dyslipidemia, female gender after menopause and power sports. We can assume that the pulse pressure represents in addition to the systolic and diastolic pressure an important prognostic marker of cardiovascular morbidity and mortality. For the time being we do not know any optimal values of pulse pressure for various age strata of normotensive and hypertensive subjects. Therapeutically we can influence the pulse pressure by means of diuretics, angiotensin converting enzyme inhibitors, angiotensin II receptor antagonists, calcium antagonists and their combinations. In young patients suffering from recent hypertension the decrease of pulse pressure values measured by means of sphygmomanometry during a 3-months betaxolol therapy was statistically significant (-4,6 mmHg, P< 0,001). The decrease of pulse pressure values measured by means of continuous ambulatory monitoring was statistically significant (-1,5 mmHg, P < 0,005) only during the day time (6-22 h), but during 24h and night time (22-6 h) it was non-significant.
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