24hodinová kontrola krevního tlaku a trough/peak ratio retardovaného metoprololu u pacientu s cerstve zjistenou hypertenzí.

Title in English 24-hour blood pressure control and trough/peak ratio of slow release metoprolole in patients with newly diagnosed hypertension.


Year of publication 2003
Type Article in Periodical
Magazine / Source Lékarské listy
MU Faculty or unit

Faculty of Medicine

Field Cardiovascular diseases incl. cardiosurgery
Keywords metoprolole; hypertension; trough/peak ratio
Description One of the important characteristic features of the new antihypertensives drugs is its 24-hour effectiveness. If the drug reaches the mean trough/peak over 50% it can be dosed once daily. We evaluated 30 patients with newly diagnosed essential hypertension before and after the 3months of treatment with average dose of 150mg slow release metoprolole once daily. Blood pressure (BP)was measured using 24hour ambulatory blood pressure monitoring according to WHO criteria. For the peak value we used the mean BP from the 3rd - 6th hour after the using of metoprolole, for the trough value the mean BP from the 22nd - 24th hour of the measurement was used, 30 minutes after getting up in the morning and excluding the influence of the hospital surroundings. Results: 1. Metoprolole decreased 24-hour systolic BP by 10,4 +- 7,3 mmHg, P < 0,001, 24-hour diastolic BP by 8,5 +- 5,2 mmHg, P < 0,001, and 24-hour heart rate by 9,6 +- 8,7 beat/minute, P < 0,001. 2. Trough/peak ratio slow release metoprolole is 78% by the systolic BP, and it is 72% by the diastolic BP. Conclusions: 1. Slow release metoprolole has the value trough/peak over 70% and it can be dosed once daily. 2. Slow release metoprolole once daily statistically significant lower 24-hour blood pressure and heart rate.
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