Relationship between 17q21 locus and adult asthma in Czech population
| Authors | |
|---|---|
| Year of publication | 2011 |
| Type | Article in Periodical |
| Magazine / Source | Human Immunology |
| MU Faculty or unit | |
| Citation | |
| Doi | http://dx.doi.org/10.1016/j.humimm.2011.07.309 |
| Field | Pneumology |
| Keywords | Allergic asthma; ORMDL3; single nucleotide polymorphism; SNP |
| Description | Several whole-genome association studies have shown a significant link between childhood asthma and the 17q12 chromosome region. We selected tagging single nucleotide polymorphisms (SNPs) in the ORMDL3 gene (17q12) to investigate gene variability in relation to adult allergic asthma and asthma/atopy traits in the Czech Caucasians. Our findings suggest that the genetic variability in the 17q21 region may be one of the risk factors also for adult asthma, especially in males. |
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