Radioterapie primárních kostních nádorů
| Title in English | Radiotherapy of primary bone tumours |
|---|---|
| Authors | |
| Year of publication | 2016 |
| Type | Article in Periodical |
| Magazine / Source | Ortopedie |
| MU Faculty or unit | |
| Citation | |
| Field | Oncology and hematology |
| Keywords | radiotherapy; local control; osteosarcoma; Ewing's sarcoma; chordoma; chondrosarcoma |
| Description | The most common primary bone tumours are osteosarcoma, Ewing's sarcoma, chordoma and chondrosarcoma. Their treatment requires a multimodal approach, the resectability is an important prognostic factor. Radiotherapy is an active modality for assuring local control and has its defined role in the treatment of primary bone tumours. It is recommended as standard part of management in inoperable Ewing's sarcoma tumours, in cases of subtotal resections or poor histological responses to neoadjuvant chemotherapy. In chordoma and chondrosarcoma, radiotherapy is reserved for clinical situations where complete surgery cannot be achieved. However, biological nature of these tumours requires the use of a high total doses of 60-78 Gy. Radiotherapy of osteosarcoma, that supposed to be radioresistant, seems to be effective in particular cases, especially in case of non-radical surgery. The therapeutic benefit of irradiation is always considered against the risk of acute and late side effects. |